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KMID : 0387820060130020218
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Clinical Pediatric Hematology-Oncology
2006 Volume.13 No. 2 p.218 ~ p.221
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A Case of Lupus-like Systemic Lupus Erythematosus with Antiphospholipid Syndrome Presented with Tendency for Coagulopathy
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Ryu Eo-Young
Jang Sun-Hwa
Yeom Jung-Sook
Park Eun-Sil
Seo Ji-Hyun
Lim Jae-Young
Park Chan-Hoo
Woo Hyang-Ok
Youn Hee-Shang
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Abstract
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Lupus-like SLE with antiphospholipid syndrome (APS) is a well-described entity that consists of APS and also 1～3 American College of Rheumatology criteria of SLE. We report a case of Lupus-like SLE with antiphospholipid antibodies that presented with thrombosis (skin and pulmonary). The laboratory findings showed that his platelet count was decreased and PT and the aPTT were prolonged. Several clotting factors decreased, including factor 8 and 9 and antibody to factor 8 and 9 were positive. Coombs test ,anticoagulants and anticardiolipid antibody (IgG and IgM) were positive. After cyclophosphamide and steroid therapy, his thrombotic phenomenon ceased gradually, and laboratory findings became normalized. We suggested that this condition may be a feature of preliminary state of full-blown SLE. We recommend therapy for Lupus-like SLE with antiphospholipid syndrome be directed on SLE with antiphospholipid syndrome rather than on primary APS (PAPS).
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KEYWORD
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Antiphospholipid syndrome, Lupus-like SLE
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